Development of a multicellular organism requires tight control of cell proliferation,
differentiation and polarized cell movements to ensure the correct assembly of cells into complex tissues.
The same molecular mechanisms that normally guide these biological processes in the developing embryo,
maintain tissue homeostasis in the adult.
When disrupted, they are the underlying cause of degenerative diseases, tumor formation and, ultimately, aging.
Focusing on the mammary gland, our group operates at the exciting interface of regenerative medicine and fundamental cancer research. We are specifically interested in understanding and manipulating the behavior and control of Wnt-responsive stem cells in normal development and breast cancer. For this, we use a combination of in vitro and in vivo approaches, including lineage tracing analyses and primary three-dimensional organoid cultures.
Read more about our research (for scientists)
Read more about our research (for non-scientists, in English)
Lees meer over ons onderzoek en de aansluiting bij de Nationale Wetenschapsagenda (voor leken, in het Nederlands)
We enjoy talking about our research (or science in general) to a wide range of audiences. Whether it is kids, high school students or interested adults, we welcome opportunities to communicate our fascination for the human body (and what goes on inside it at the level of DNA, proteins and cells) to the general public.
Our work has received financial support from the following sources: