principal investigator (complete CV here)
Renée received her MSc from the Vrije Universiteit (VU) (1999, cum laude) and her PhD from the University of Amsterdam (UvA) (2005, also cum laude). She performed her PhD training with Anton Berns at the Netherlands Cancer Institute and did a postdoc with Roel Nusse at Stanford University.
In 2013 she was appointed as MacGillavry fellow and tenure track assistant professor at the UvA. She was promoted to associate professor (with tenure) in 2017.
Renée is the recipient of an EMBO long-term fellowship (2007), a KWF fellowship for fundamental cancer research (2007) and a KWF career research award (2013). In 2014 she was awarded a highly competitive VIDI grant by the Netherlands Research Council (NWO) to expand her research in the area of mammary stem cell biology.
photo: Liesbeth Dingemans
Amber received her BASc degree in 2013, after completing internships at the Utrecht Medical Center and the Netherlands Cancer Institute. She briefly worked as a technician for Jos Jonkers at the Netherlands Cancer Institute in 2013 and joined the group in November of the same year. She has established the primary three-dimensional organoid culture system in the lab and continues to explore other complex in vitro culture systems. In December 2017 her temporary position became permanent.
Postdocs & PhD students
Larissa received her MSc in Molecular and Cellular Biology at the Université Pierre et Marie Curie in 2013, specialising in Developmental Biology. She then pursued her PhD work in the laboratory of Silvia Fre at the Institut Curie in Paris, where she focused in the identification and molecular characterisation of an intestinal cancer stem cell population expressing the Notch1 receptor. Larissa was awarded her PhD in 2017. She joined the group in January 2018 to work on the role of aberrant Wnt signalling in breast cancer, using both mouse and human (breast cancer) three-dimensional organoid cultures.
Katrin received her MSc degree in Human Biology from the University of Marburg in 2008. During her PhD with Martin Eilers at the Biocenter in Würzburg, Katrin focused on MYC oncoproteins and developed her passion for mammary gland biology and breast cancer research. She received her PhD in 2016 (summa cum laude).
Katrin joined the lab in January 2015 and works on identifying and manipulating the mammary stem cell niche. In 2016, she was awarded a 2-year Marie Skłodowska-Curie Actions Individual Fellowship. In collaboration with the UvA-FNWI career service, Katrin also established the SILS career lunch series, which aims to inspire PhD students and postdocs to take charge of their own career development by exploring different career perspectives.
Yorick received his BSc from Utrecht University in 2013. In 2017 he obtained his MSc degree from the same university, after performing internships at the University Medical Center in Utrecht and at Stanford University (USA). He joined the group in February 2017 and works on identifying the mammary stem cell niche.
Nika received her MSc degree from the Vrije Universiteit in Amsterdam in December 2013. During the Master Oncology she worked as an intern in the labs of Tom Wurdinger (VUmc Cancer Center Amsterdam) and Puck Knipscheer (Hubrecht Institute, Utrecht). In 2014 she did an extracurricular internship in the lab of David Virshup at Duke-NUS Graduate Medical School in Singapore, where she worked on Wnt signaling. Nika joined the group in October 2014 and works on identifying the mammary stem cell niche.
In 2016 Saskia received her MSc degree (cum laude) from the University of Amsterdam, where she followed the track "Cell Biology and Advanced Microscopy". During her master she did an internship in the van Amerongen lab and went abroad for her second internship with Nadine Peyriéras (CNRS, Gif-sur-Yvette France). Saskia returned to the group to start a PhD in September 2016 and uses advanced microscopy techniques to further elucidate molecular mechanisms of Wnt signaling. This project is carried out in close collaboration with Dr. Mark Hink.
After completing internships in the labs of Hans Clevers (Hubrecht Institute, Utrecht) and Magdalena Zernicka-Goetz (Cambridge University, UK), Anoeska received her MSc degree from Utrecht University in 2013. She joined the group in March 2014 and works on identifying the mammary stem cell niche. In addition, she also uses CRISPR technology to modify genes implicated in Wnt signal transduction with the goal of visualizing Wnt signaling in real time.
Current Wntlab students
Katja joined the group in January 2018 for her first MSc internship as part of the UvA Biomedical Sciences program (Oncology track). She works under the supervision of Nika on the regulation of Wnt expression in the mammary gland.
Sanne joined the group in January 2018 for her first MSc internship as part of the UvA Biomedical Sciences program (Cell Biology and Advanced Microscopy track). She works under the supervision of Saskia on the functional imaging of Wnt signal transduction.
Marius joined the group in February 2018 for his BSc internship as part of the UvA Biomedical Sciences program (excellence track). He works under the supervision of Katrin on the regulation of Wnt expression in the mammary gland.
Isabel joined the group in January 2018 for her MSc internship as part of the UvA Biomedical Sciences program (Oncology track). She works under the supervision of Amber on the role of hyperactive Wnt signaling in breast cancer.
Roan joined the group in February 2018 for his BSc internship as part of the UvA Biomedical Sciences program (excellence track). He works under the supervision of Yorick on the regulation of Wnt expression in the mammary gland.